Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis

• मुख्य लेखकों: Xing-Qiang Dong (लेखक), Li-Kai Chu (लेखक), Xu Cao (लेखक), Qian-Wei Xiong (लेखक), Yi-Ming Mao (लेखक), Ching-Hsien Chen (लेखक), Yun-Li Bi (लेखक), Jun Liu (लेखक), Xiang-Ming Yan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

ABSTRACTRenal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). The chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but...