Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis

• Main Authors: Xing-Qiang Dong (Author), Li-Kai Chu (Author), Xu Cao (Author), Qian-Wei Xiong (Author), Yi-Ming Mao (Author), Ching-Hsien Chen (Author), Yun-Li Bi (Author), Jun Liu (Author), Xiang-Ming Yan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTRenal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). The chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but...