Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

• Main Authors: Jason Yuen (Author), Abhinav Goyal (Author), Aaron E. Rusheen (Author), Abbas Z. Kouzani (Author), Michael Berk (Author), Jee Hyun Kim (Author), Susannah J. Tye (Author), Osama A. Abulseoud (Author), Tyler S. Oesterle (Author), Charles D. Blaha (Author), Kevin E. Bennet (Author), Kendall H. Lee (Author), Yoonbae Oh (Author), Hojin Shin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Opioids are the leading cause of overdose death in the United States, accounting for almost 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising new treatment for substance use disorders. Here, we hypothesized that VTA DBS would modulate both the dopaminergic and respirat...