Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor

• Main Authors: Rafaela R. Silva (Author), Lucas T. Parreiras- (Author), Thais E.T. Pompeu (Author), Diego A. Duarte (Author), Carlos A.M. Fraga (Author), Eliezer J. Barreiro (Author), Ricardo Menegatti (Author), Claudio M. Costa-Neto (Author), François Noël (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D2 receptor (D2R) ligand with antipsychotic-like activities in rodent models of schizophrenia. In order to better understand the molecular mechanism of action of LASSBio-579 and of its main metabolite,...