Pharmacokinetics and bioavailability of a new long-acting insulin analog in healthy Chinese volunteers: an open, randomized, single-dose, two-period and two-sequence cross-over study

• Main Authors: Ke-Guang Chen (Author), Ye-Hui Zhang (Author), Pan-Pan Ye (Author), Xue-Hu Gao (Author), Lin-Lin Song (Author), Hai-Yan Zhou (Author), Qian Li (Author), Fu-Rong Zhao (Author), Jin-Yi Shi (Author), Xin-Mei Yang (Author), Kai Shen (Author), Sheng Feng (Author), Wei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: INS068 is a novel, soluble, and long-acting insulin analog. In this study, we evaluated the pharmacokinetics and relative bioavailability of two formulations of INS068 in healthy Chinese subjects: a reference formulation packaged in vials and administered via syringe (R), and a test form...