2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats

• Main Authors: Pei-pei Yuan (Author), Meng Li (Author), Qi Zhang (Author), Meng-nan Zeng (Author), Ying-ying Ke (Author), Ya-xin Wei (Author), Yang Fu (Author), Xiao-ke Zheng (Author), Wei-sheng Feng (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Renal fibrosis with Renin-angiotensin-aldosterone system (RAAS) activation and oxidative stress are one of the major complications in hypertension. 2-phenylacetamide (PA), a major active component of Lepidium apetalum Willd. (L.A), has numerous pharmacological effects. Its analog...