Macromolecular Structure Assembly as a Novel Antibiotic Target
This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second ta...
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| Format: | Book |
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MDPI AG,
2022-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second target that should be investigated. RNA polymerase protein structural interactions are a third potential target. Finally, disruption of ribosomal subunit biogenesis represents a fourth important target that can be further investigated. Methods to examine these possibilities are discussed. |
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| Item Description: | 10.3390/antibiotics11070937 2079-6382 |