Macromolecular Structure Assembly as a Novel Antibiotic Target
This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second ta...
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| Format: | Book |
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MDPI AG,
2022-07-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f4ee6dc593c94ae7a0a2b1e63bb4cf9a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Scott Champney |e author |
| 245 | 0 | 0 | |a Macromolecular Structure Assembly as a Novel Antibiotic Target |
| 260 | |b MDPI AG, |c 2022-07-01T00:00:00Z. | ||
| 500 | |a 10.3390/antibiotics11070937 | ||
| 500 | |a 2079-6382 | ||
| 520 | |a This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second target that should be investigated. RNA polymerase protein structural interactions are a third potential target. Finally, disruption of ribosomal subunit biogenesis represents a fourth important target that can be further investigated. Methods to examine these possibilities are discussed. | ||
| 546 | |a EN | ||
| 690 | |a penicillin-binding proteins | ||
| 690 | |a DNA polymerase III | ||
| 690 | |a RNA polymerase | ||
| 690 | |a ribosomes | ||
| 690 | |a crystallography | ||
| 690 | |a antisense oligonucleotides | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antibiotics, Vol 11, Iss 7, p 937 (2022) | |
| 787 | 0 | |n https://www.mdpi.com/2079-6382/11/7/937 | |
| 787 | 0 | |n https://doaj.org/toc/2079-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f4ee6dc593c94ae7a0a2b1e63bb4cf9a |z Connect to this object online. |