Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax).

• Main Authors: Claire Y-H Huang (Author), Richard M Kinney (Author), Jill A Livengood (Author), Bethany Bolling (Author), John J Arguello (Author), Betty E Luy (Author), Shawn J Silengo (Author), Karen L Boroughs (Author), Janae L Stovall (Author), Akundi P Kalanidhi (Author), Aaron C Brault (Author), Jorge E Osorio (Author), Dan T Stinchcomb (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have developed a manufacturing strategy that can improve the safety and genetic stability of recombinant live-attenuated chimeric dengue vaccine (DENVax) viruses. These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1-4 in the replicative background of the a...