Synthesis, Characterization and Antioxidant Properties of a New Lipophilic Derivative of Edaravone

• Main Authors: Cristina Minnelli (Author), Emiliano Laudadio (Author), Roberta Galeazzi (Author), Dario Rusciano (Author), Tatiana Armeni (Author), Pierluigi Stipa (Author), Mattia Cantarini (Author), Giovanna Mobbili (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As part of a program aimed to obtain antioxidants able to interact with cell membrane, edaravone (EdV, 3-methyl-1-phenyl-2-pyrazolin-5-one), a well-known free radical scavenger, has been modified by alkylation at its allylic position (4) with a C-18 hydrocarbon chain, and the increased lipophilicity...