Cover Image

Synthesis, Characterization and Antioxidant Properties of a New Lipophilic Derivative of Edaravone

As part of a program aimed to obtain antioxidants able to interact with cell membrane, edaravone (EdV, 3-methyl-1-phenyl-2-pyrazolin-5-one), a well-known free radical scavenger, has been modified by alkylation at its allylic position (4) with a C-18 hydrocarbon chain, and the increased lipophilicity...

Full description

Saved in:

Bibliographic Details
Main Authors:	Cristina Minnelli (Author), Emiliano Laudadio (Author), Roberta Galeazzi (Author), Dario Rusciano (Author), Tatiana Armeni (Author), Pierluigi Stipa (Author), Mattia Cantarini (Author), Giovanna Mobbili (Author)
Format:	Book
Published:	MDPI AG, 2019-07-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Monoalkylated Epigallocatechin-3-gallate (C18-EGCG) as Novel Lipophilic EGCG Derivative: Characterization and Antioxidant Evaluation
by: Cristina Minnelli, et al.
Published: (2020)

Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants
by: Nadia Gruber, et al.
Published: (2021)

Insights into the Antioxidant Mechanism of Newly Synthesized Benzoxazinic Nitrones: In Vitro and In Silico Studies with DPPH Model Radical
by: Stefania Marano, et al.
Published: (2021)

Meldonium Inhibits Cell Motility and Wound-Healing in Trabecular Meshwork Cells and Scleral Fibroblasts: Possible Applications in Glaucoma
by: Cristina Minnelli, et al.
Published: (2023)

Synthesis, Characterization and Assessment of Antioxidant and Melanogenic Inhibitory Properties of Edaravone Derivatives
by: R. Divya Mohan, et al.
Published: (2024)

Glyoxalase 2: Towards a Broader View of the Second Player of the Glyoxalase System
by: Andrea Scirè, et al.
Published: (2022)

Side Effects of Curcumin: Epigenetic and Antiproliferative Implications for Normal Dermal Fibroblast and Breast Cancer Cells
by: Laura Cianfruglia, et al.
Published: (2019)

Role of Tobramycin in the Induction and Maintenance of Viable but Non-Culturable <i>Pseudomonas aeruginosa</i> in an In Vitro Biofilm Model
by: Gianmarco Mangiaterra, et al.
Published: (2020)

Synthesis of Lipophilic Esters of Tyrosol, Homovanillyl Alcohol and Hydroxytyrosol
by: Roberta Bernini, et al.
Published: (2019)

Selective Enzymatic Esterification of Lignin-Derived Phenolics for the Synthesis of Lipophilic Antioxidants
by: Marta Martinez-Garcia, et al.
Published: (2023)

Insights into the Molecular Mechanisms of Eg5 Inhibition by (+)-Morelloflavone
by: Tomisin Happy Ogunwa, et al.
Published: (2019)

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation
by: Ankit Parikh, et al.
Published: (2017)

Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
by: Akula S. N. Murthy, et al.
Published: (2022)

Cost-effectiveness of edaravone dexborneol versus edaravone for the treatment of acute ischemic stroke in China: Based on the TASTE study
by: Fenghao Shi, et al.
Published: (2022)

Role of edaravone in managemant of septic peritonitis
by: Ghada Fouad Elbaradey, et al.
Published: (2016)

Edaravone in the treatment of concussion and post-concussion syndrome
by: O.A. Halushko
Published: (2023)

Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases
by: Manesh Nautiyal, et al.
Published: (2019)

Two Novel Lipophilic Antioxidants Derivatized from Curcumin
by: Tao Liu, et al.
Published: (2022)

A Green Lipophilization Reaction of a Natural Antioxidant
by: Valeria Pappalardo, et al.
Published: (2023)

Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704
by: Dong Wook Kang, et al.
Published: (2021)

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer's agents
by: Luke S. Zondagh, et al.
Published: (2020)

Experimental and theoretical study on structure-tautomerism among edaravone, isoxazolone, and their heterocycles derivatives as antioxidants
by: Auriekson N. Queiroz, et al.
Published: (2020)

Development and characterization of photoprotective nanoemulsions containing Babassu (Orbignya phalerata Mart.) lipophilic extract
by: Italo Rennan Sousa Vieira, et al.
Published: (2023)

Acid-base and lipophilic properties of peptide nucleic acid derivatives
by: Pramod Thakare, et al.
Published: (2021)

Synthesis, Characterization and Antioxidant Property of Quercetin-Tb(III) Complex
by: Jafar Ezzati Nazhad Dolatabadi, et al.
Published: (2014)

Evaluation of edaravone against radiation-induced oral mucositis in mice
by: Noriko Nakajima, et al.
Published: (2015)

Drug-like Properties and Fraction Lipophilicity Index as a combined metric
by: Anna Tsantili-Kakoulidou, et al.
Published: (2021)

Effect of Carrier Lipophilicity and Preparation Method on the Properties of Andrographolide-Solid Dispersion
by: Guowei Zhao, et al.
Published: (2019)

Antioxidant Effect of Edaravone on the Development of Preimplantation Porcine Embryos against Hydrogen Peroxide-Induced Oxidative Stress
by: Geon-Yeop Do, et al.
Published: (2015)

Comparison of the lipophilicity parameters of drospirenone and lynestrenol
by: Agnieszka Kusztal, et al.
Published: (2022)

Molecular Mechanisms and Therapeutic Potential of Gabapentin with a Focus on Topical Formulations to Treat Ocular Surface Diseases
by: Dario Rusciano
Published: (2024)

Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia
by: Marwa Atallah, et al.
Published: (2021)

Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger
by: Yoshinori Akiyama, et al.
Published: (2007)

Effects of Edaravone on Singlet Oxygen Released From Activated Human Neutrophils
by: Piyanart Sommani, et al.
Published: (2007)

Application of a free radical scavenger edaravone in patients with hemorrhagic stroke
by: O.A. Halushko
Published: (2021)

Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis
by: HaEun Cho, et al.
Published: (2020)

Transfer Investigations of Lipophilic Drugs from Lipid Nanoemulsions to Lipophilic Acceptors: Contributing Effects of Cholesteryl Esters and Albumin as Acceptor Structures
by: Sabrina Knoke, et al.
Published: (2021)

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation
by: Lidia de Bari, et al.
Published: (2020)

Edaravone Protects against Vascular Oxidative Damage Induced by AAPH in Chick Embryo
by: Xin Wan, et al.
Published: (2016)

Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone
by: Helene Ismail, et al.
Published: (2020)