Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

• Main Authors: I-Chun Lai (Author), Gi-Ming Lai (Author), Jyh-Ming Chow (Author), Hsin-Lun Lee (Author), Chuan-Feng Yeh (Author), Chi-Han Li (Author), Jiann-Long Yan (Author), Shuang-En Chuang (Author), Jacqueline Whang-Peng (Author), Kuan-Jen Bai (Author), Chih-Jung Yao (Author)
• Format: Book
• Published: BMC, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets for therapeutic developments. In a relatively limited subset of NSCLC,...