8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model

• Main Authors: Nitesh Shirsath (Author), Karin Wagner (Author), Simone Tangermann (Author), Michaela Schlederer (Author), Christian Ringel (Author), Lukas Kenner (Author), Bernhard Brüne (Author), Peter Wolf (Author)
• Format: Book
• Published: Medical Journals Sweden, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and ps...