Normative range of various serum hormonal parameters among Indian women of reproductive age: ICMR-PCOS task force study outcomeResearch in context

• Main Authors: Mohd Ashraf Ganie (Author), Subhankar Chowdhury (Author), Vanita Suri (Author), Beena Joshi (Author), Prasanta Kumar Bhattacharya (Author), Sarita Agrawal (Author), Neena Malhotra (Author), Rakesh Sahay (Author), Puthiyaveettil Khadar Jabbar (Author), Abilash Nair (Author), Roya Rozati (Author), Amlin Shukla (Author), Rabiya Rashid (Author), Idrees A. Shah (Author), Haroon Rashid (Author), Imtiyaz Ahmad Wani (Author), Taruna Arora (Author), Bharati Kulkarni (Author), Bharti Kulkarni (Author), V. Sreenivas (Author), Mukesh Srivastava (Author), Parvaiz Koul (Author), Zafar Amin Shah (Author), Shariq Masoodi (Author), Tabassum Parvez (Author), Ghulam Nabi Yatoo (Author), Naseer Ahmed (Author), Tariq Gojwari (Author), Muzafar Wani (Author), Seema Qayoom (Author), Wahid Khan (Author), Rama Walia (Author), Dipankar De (Author), Aashima Arora (Author), Tulika Singh (Author), Neena Khanna (Author), Nitish Naik (Author), Shyam Prakash (Author), Nandita Gupta (Author), Rajesh Sagar (Author), Jai Bhagwan Sharma (Author), Devasenathipathy Kandasamy (Author), Narendra Kuber Bodhey (Author), Eli Mohapatra (Author), Sabah Siddiqui (Author), Gourisankar Kamilya (Author), Archana Singh (Author), Pradip Mukhopadhyay (Author), Mousumi Mukhopadhyay (Author), Nehar Ranjan Sarkar (Author), Alice Abraham Ruram (Author), Jessy Abraham (Author), Saroj Kumar Pati (Author), Dibakar Sahu (Author), Lokesh Kumar Singh (Author), Donboklang Lynser (Author), Manika Agrawal (Author), Ashok Anand (Author), Shahina Begum (Author), Anushree Patil (Author), Shrabani Mukherjee (Author), Hemangini Thakkar (Author), Aruna Ramaiah (Author), Lakshman Rao (Author), Sudha Bindu (Author), Malathi Ponnuru (Author), Nadeem Ahmad (Author), Sujatha Rani (Author), Aleem Ahmed Khan (Author), Sultan Rizwan Ahmed (Author), Prabhakar Rao (Author), C. Nirmala (Author), Anuja Elizabeth George (Author), Jayasree Leelamma (Author), Jayakumari (Author), Gaurav Thakur (Author), Saba Noor (Author), Shaikh Sharmeen (Author), Gaivee Vinam Meshram (Author), Shouvik Choudhury Aafia Rashid (Author), Wasia Showkat (Author), Rohina Bashir (Author), Pieu Adhikary (Author), Subhasish Pramanik (Author), Rahul Harish (Author), Mudasir Makhdoomi (Author), Mudasir Fayaz (Author), Nafeez Rehman (Author), Neha Ravi (Author), Ajay Kumar (Author), Siffali Chandrakar (Author), Nithlesh Kumar (Author), Sudipta Banerjee (Author), Gazala Hasan (Author), Nitin Deshpande (Author), Himali Vadhan (Author), Rita Parab (Author), Humaira Minhaj (Author), Balaji Bhasker (Author), Shaik Iqbal Ahmed (Author), Ram Babu (Author), Arya Suresh (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Summary: Background: The hormonal profile varies considerably with age, gender, ethnicity, diet or physiological state of an individual. Limited population-specific studies have studied the variations in hormonal parameters among apparently healthy women. We aimed to analyse the biological reference interval for various hormonal parameters in the reproductive-aged healthy Indian women. Methods: Out of 3877 participants that were clinically evaluated, 1441 subjects were subjected to laboratory investigations. All participants underwent a detailed clinical, biochemical and hormonal profiling. The hormone analysis was carried out at a single centre using a uniform methodology. Among the participants evaluated for biochemical and hormonal parameters, subjects that presented any abnormal profile or had incomplete investigations (n = 593) were excluded for further analysis. Findings: The mean age (±SD) of the subjects retained in the final analysis (n = 848) was 29.9 (±6.3) years. In the present study, the biological reference interval (2.5th-97.5th centile) observed were: serum T4: μg/dL (5.23-12.31), TSH: μg/mL (0.52-4.16) and serum prolactin: ng/mL (5.13-37.35), LH: mIU/mL (2.75-20.68), FSH: mIU/mL 2.59-15.12), serum total testosterone: ng/mL (0.06-0.68), fasting insulin: mIU/mL (1.92-39.72), morning cortisol: μg/dL (4.71-19.64), DHEAS:μg/dL (50.61-342.6) and SHBG: nmol/L (21.37-117.54). Unlike T4, TSH, LH, and E2, the biological reference interval for prolactin, FSH, testosterone, C-peptide insulin and DHEAS varied when the subjects were stratified by age (p < 0.05). The comparative analysis showed marginal differences in the normative ranges for the hormones analysed among different populations. Interpretation: Our first large composite data on hormonal measures will benefit future endeavours to define biological reference intervals in reproductive-aged Indian women. Funding: The study was financially supported by the grant-in-aid from ICMR vide file No:5/7/13337/2015-RBMH.

Item Description

2772-3682
10.1016/j.lansea.2023.100226