Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

• Main Authors: Barbara L Mui (Author), Ying K Tam (Author), Muthusamy Jayaraman (Author), Steven M Ansell (Author), Xinyao Du (Author), Yuen Yi C Tam (Author), Paulo JC Lin (Author), Sam Chen (Author), Jayaprakash K Narayanannair (Author), Kallanthottathil G Rajeev (Author), Muthiah Manoharan (Author), Akin Akinc (Author), Martin A Maier (Author), Pieter Cullis (Author), Thomas D Madden (Author), Michael J Hope (Author)
• 格式: 圖書
• 出版: Elsevier, 2013-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to humans. This success has motivated research to identif...