Evaluationoof0theoRole0ofoGabapentin0and/oroOmega-30in0Uremic Pruritusofor0PatientsoUndergoing0Hemodialysis0

• Main Authors: Sinan Forat Hussein (Author), Kadhim Ali Kadhim (Author), Ali Jassim Al_Sultani (Author), Saad Abdulrahman Hussain (Author)
• Format: Book
• Published: College of Pharmacy / Mustansiriyah University, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Uremicopruritus,0isochronic0itchingothat0occursoin0patientsowith0advancedoor0 end-stage renal0disease.oIt0isoone0ofocommon0symptomsoinopatients00with00end-stage renal0 diseaseowith0approximatelyo60-90%0ofopatients0on0hemodialysis(HD) suffering0fromothis0problem. This study wasodesigned0to evaluate theoefficacy0and safety of prescribing Gabapentinoand0Omega-3 in combination or aloneofor0relieving uremicopruritus0in Iraqi patients undergoing0hemodialysis. The resultsoshowed0that all the threeoinvolved0regimens0(gabapentin, omega-3,0and the combinationoof0both drugs) had0significantly reduced the pruritus score. Furthermore,0theocombination0was significantlyosuperior0tooother0regimens in reducingopruritus 0score, owhile0no0significant effect0wasoobserved0by oallothe regimensoon0interleukin-6oor0on parathyroid hormone serum0levels.In Conclusion Gabapentin0100mgoplus01000mg0omega-30based fishooil capsules containing 120mg0DHA and0180mg0EPA isosuperior0to each drug alone0in reducing pruritus scoreoin0a0sample0of Iraqi0patients.

Item Description

10.32947/ajps.v17i2.157
1815-0993
2959-183X