Agonistic nanobodies and antibodies to human VISTA

• Main Authors: Yu-Heng Vivian Ma (Author), Amanda Sparkes (Author), Ema Romão (Author), Shrayasee Saha (Author), Jean Gariépy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The V-domain Ig Suppressor of T-cell Activation (VISTA) is an immune checkpoint regulator that suppresses immune responses and is readily expressed on human and murine myeloid cells and T cells. This immunosuppressive pathway can be activated using VISTA agonists. Here, we report the development of...