Anticataract activity of ethanolic extract from Hippobroma longiflora (L.) G.Don leaves: Ex vivo investigation
Context: In Aceh, Hippobroma longiflora, known as kitolodby the locals, is believed to possess medicinal benefits such as anticataract. Aims: To investigate the anticataract activity of ethanolic extract from H. longiflora leaves ex vivo. Methods: The dried fine powder of H. longiflora was macerated...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
GarVal Editorial Ltda.,
2023-09-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f5a899f19b7b49b7b75efb5f4ee6d0bf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Eva Imelda |e author |
| 700 | 1 | 0 | |a Khairan Khairan |e author |
| 700 | 1 | 0 | |a Rodiah R. Lubis |e author |
| 700 | 1 | 0 | |a Pati Kemala |e author |
| 700 | 1 | 0 | |a Utari Zulfiani |e author |
| 700 | 1 | 0 | |a Suci Rahayu |e author |
| 700 | 1 | 0 | |a Ghazi M. Idroes |e author |
| 700 | 1 | 0 | |a Sarra M. Adev |e author |
| 700 | 1 | 0 | |a Nur B. Maulydia |e author |
| 700 | 1 | 0 | |a Rinaldi Idroes |e author |
| 245 | 0 | 0 | |a Anticataract activity of ethanolic extract from Hippobroma longiflora (L.) G.Don leaves: Ex vivo investigation |
| 260 | |b GarVal Editorial Ltda., |c 2023-09-01T00:00:00Z. | ||
| 500 | |a 10.56499/jppres23.1691_11.5.833 | ||
| 500 | |a 0719-4250 | ||
| 520 | |a Context: In Aceh, Hippobroma longiflora, known as kitolodby the locals, is believed to possess medicinal benefits such as anticataract. Aims: To investigate the anticataract activity of ethanolic extract from H. longiflora leaves ex vivo. Methods: The dried fine powder of H. longiflora was macerated using ethanol at room temperature, and the concentrated extract was prepared in concentrations ranging from 100 to 300 μg/mL. The cataract model was established by using goat lens induced with H2O2 and later exposed to the extract for treatment. Anti-cataract activity was assessed by observing the change in lens opacity. Further, malondialdehyde levels and activities of endogenous antioxidants (superoxide dismutase, glutathione peroxidase, and catalase). Results: The apparent cataract opacity reduced after the exposure of the extract was observed macroscopically. The cataract eyes experienced a significant increase (p<0.05) in malondialdehyde level and a significant reduction (p<0.05) in the activities of superoxide dismutase, glutathione peroxidase, and catalase. The pathologic conditions could be reversed by introducing the extract with a concentration as low as 100 μg/mL (p<0.05). Conclusions: The ethanolic extract of H. longiflora leaf has a potential anticataract effect by ameliorating oxidative stress-related biocompounds. | ||
| 546 | |a EN | ||
| 546 | |a ES | ||
| 690 | |a catalase | ||
| 690 | |a cataract | ||
| 690 | |a glutathione peroxidase | ||
| 690 | |a malondialdehyde | ||
| 690 | |a superoxide dismutase | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 5, Pp 833-840 (2023) | |
| 787 | 0 | |n https://jppres.com/jppres/pdf/vol11/jppres23.1691_11.5.833.pdf | |
| 787 | 0 | |n https://doaj.org/toc/0719-4250 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f5a899f19b7b49b7b75efb5f4ee6d0bf |z Connect to this object online. |