Optical density of bone repair after implantation of homogenous demineralized dentin matrix in diabetic rabbits

• Main Authors: Mônica Fernandes Gomes (Author), Maria Fernanda de Souza Setúbal Destro (Author), Éfani Caroline de Freitas Banzi (Author), Evanice Menezes Marçal Vieira (Author), Aline Rose Cantarelli Morosolli (Author), Maria das Graças Vilela Goulart (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica, 2008-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1590/S1806-83242008000300015; 1806-8324
• Keywords: Dentin; Bone regeneration; Guided tissue regeneration; Bone density; Diabetes mellitus; Dentistry; RK1-715
• Source: Brazilian Oral Research, Vol 22, Iss 3, Pp 275-280 (2008)

This research evaluated the bone repair process after implantation of homogenous demineralized dentin matrix (HDDM) in surgical defects in the parietal bone of rabbits with alloxan-induced diabetes, using a polytetrafluorethylene (PTFe) barrier for guided bone regeneration. Thirty-six rabbits were used and divided into four groups: control (C, n = 12), diabetic (D, n = 12, left parietal bone), diabetic with PTFe (D-PTFe, same 12 rabbits, right parietal bone), and diabetic with PTFe associated to HDDM (D-PTFe+HDDM, n = 12). Bone defects were created in the parietal bone of the rabbits and the experimental treatments were performed, where applicable. The rabbits were sacrificed after 15, 30, 60 and 90 days. The bone defects were examined radiographically and by optical density (ANOVA and Tukey test, p < .05). The radiographic findings showed that the D-PTFe+HDDM group presented greater radiopacity and better trabecular bone arrangement when compared to that of the C, D and D-PTFe groups. The statistical analysis showed significant differences in the optical density of the newly formed bone among the studied groups. It was possible to conclude that HDDM was biocompatible in diabetic rabbits.