Dietary sugars, not lipids, drive hypothalamic inflammation

• Main Authors: Yuanqing Gao (Author), Maximilian Bielohuby (Author), Thomas Fleming (Author), Gernot F. Grabner (Author), Ewout Foppen (Author), Wagner Bernhard (Author), Mara Guzmán-Ruiz (Author), Clarita Layritz (Author), Beata Legutko (Author), Erwin Zinser (Author), Cristina García-Cáceres (Author), Ruud M. Buijs (Author), Stephen C. Woods (Author), Andries Kalsbeek (Author), Randy J. Seeley (Author), Peter P. Nawroth (Author), Martin Bidlingmaier (Author), Matthias H. Tschöp (Author), Chun-Xia Yi (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate, with respect to the hypothalamic inflammatory res...