<em>Rhamnus </em><em>alaternus</em> Plant: Extraction of Bioactive Fractions and Evaluation of Their Pharmacological and Phytochemical Properties

• Главные авторы: Amine Nekkaa (Автор), Akila Benaissa (Автор), Fabrice Mutelet (Автор), Laetitia Canabady-Rochelle (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2021-02-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.
• Notes: 10.3390/antiox10020300; 2076-3921
• Keywords: <i>Rhamnus alaternus</i>; extraction processes; phytochemistry; ethnopharmacology; phytotherapy; toxicity; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 10, Iss 2, p 300 (2021)

<i>Rhamnus alaternus</i>, is a wild-growing shrub, belonging to the <i>Rhamnaceae</i> family. Widely distributed in the Mediterranean basin<i>, R. alaternus</i> is used in the usual medicine in numerous countries, mostly Tunisia, Algeria, Morocco, Spain, France, Italy, and Croatia. A large number of disorders-including dermatological complications, diabetes, hepatitis, and goiter problems-can be treated by the various parts of <i>R. alaternus</i> (i.e., roots, bark, berries, and leaves). Several bioactive compounds were isolated from <i>R. alaternus</i>, including flavonoids, anthocyanins, and anthraquinones, and showed several effects such as antioxidant, antihyperlipidemic, antigenotoxic, antimutagenic, antimicrobial, and antiproliferative. This review summarizes the updated information concerning the botanical description, distribution, extraction processes applied on <i>R. alaternus</i>, and its ethnopharmacology, toxicity, phytochemistry, and pharmacological effects.