Current research progress in identifying the mechanism of berberine in pain regulation

Pain is accompanied by high morbidity and imposes a substantial economic burden on individuals and society. Unfortunately, few effective therapeutic methods are available for pain relief. Berberine is a natural product that has attracted widespread attention in recent years. Studies have shown that...

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Main Authors: Shuai Han (Author), Ru-Bing Yan (Author), Sen Guan (Author), Wen-Jie Fan (Author), Hai-Chen Chu (Author), Yong-Xin Liang (Author)
Format: Book
Published: Elsevier, 2021-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Shuai Han  |e author 
700 1 0 |a Ru-Bing Yan  |e author 
700 1 0 |a Sen Guan  |e author 
700 1 0 |a Wen-Jie Fan  |e author 
700 1 0 |a Hai-Chen Chu  |e author 
700 1 0 |a Yong-Xin Liang  |e author 
245 0 0 |a Current research progress in identifying the mechanism of berberine in pain regulation 
260 |b Elsevier,   |c 2021-12-01T00:00:00Z. 
500 |a 2667-1425 
500 |a 10.1016/j.prmcm.2021.100019 
520 |a Pain is accompanied by high morbidity and imposes a substantial economic burden on individuals and society. Unfortunately, few effective therapeutic methods are available for pain relief. Berberine is a natural product that has attracted widespread attention in recent years. Studies have shown that berberine has various pharmacological effects, such as analgesic, anti-inflammatory, anti-bacterial, anti-oxidative stress, anti-thrombotic, anti-tumor, and hypoglycemic activity. According to the literature, berberine exerts its pain-relieving activity by downregulation of transient receptor potential vanilloid (TRPV)-1; suppression of toll-like receptor 4 (TLR4), mitogen-activated protein kinase (MAPK), and nuclear factor kappa-B (NF-κB); and modulation of μ opioid receptors. Moreover, berberine could regulate the dopamine and N-methyl-D-aspartic acid (NMDA) systems and induce the expression of Nrf2 to promote analgesia. The present literature review discusses the analgesic effects of berberine in inflammatory pain, neuropathic pain, cancer pain, chemotherapy pain, and morphine tolerance, and discusses the possible mechanism of berberine in pain regulation. 
546 |a EN 
690 |a Natural product 
690 |a Berberine 
690 |a Pain 
690 |a Inflammation 
690 |a Oxidative stress 
690 |a Other systems of medicine 
690 |a RZ201-999 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Pharmacological Research - Modern Chinese Medicine, Vol 1, Iss , Pp 100019- (2021) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S266714252100018X 
787 0 |n https://doaj.org/toc/2667-1425 
856 4 1 |u https://doaj.org/article/f61c2bdce9a94c20ba8809199248968c  |z Connect to this object online.