miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and has a high mortality rate. Although prevention and treatment of HCC has improved, it still faces poor prognosis and high mortality. miRNAs play a critical role in the tumorigenesis of HCC, but the underlying mechanism...
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Hindawi Limited,
2022-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_f6238713024c46b5a5b4e5d00fb538b4 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Chunjing Wang |e author |
700 | 1 | 0 | |a Chengcheng Li |e author |
700 | 1 | 0 | |a Rui Hao |e author |
245 | 0 | 0 | |a miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3 |
260 | |b Hindawi Limited, |c 2022-01-01T00:00:00Z. | ||
500 | |a 1466-1861 | ||
500 | |a 10.1155/2022/3121492 | ||
520 | |a Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and has a high mortality rate. Although prevention and treatment of HCC has improved, it still faces poor prognosis and high mortality. miRNAs play a critical role in the tumorigenesis of HCC, but the underlying mechanism has not been well investigated. Here, the functions and interaction between miR-559 and PARD3 were investigated in HCC cells. Increased PARD3 and decreased miR-559 expression were observed in HCC cells compared with those in normal liver cells, especially in Huh-7 cells. Studies further demonstrated that PARD3 silencing or miR-559 overexpression impaired the proliferation, autophagy, and angiogenesis in Huh-7 cells. Mechanistically, PARD3 represents a target of miR-559. Furthermore, investigations revealed that miR-559 inhibition induced the expression of PARD3, thereby enhancing cell proliferation, autophagy, and angiogenesis in Huh-7 cells. These results reveal the interaction between miR-559 and PARD3 in HCC cells and provide new insights into their potential targets as therapeutic treatment against HCC. | ||
546 | |a EN | ||
690 | |a Pathology | ||
690 | |a RB1-214 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Mediators of Inflammation, Vol 2022 (2022) | |
787 | 0 | |n http://dx.doi.org/10.1155/2022/3121492 | |
787 | 0 | |n https://doaj.org/toc/1466-1861 | |
856 | 4 | 1 | |u https://doaj.org/article/f6238713024c46b5a5b4e5d00fb538b4 |z Connect to this object online. |