miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and has a high mortality rate. Although prevention and treatment of HCC has improved, it still faces poor prognosis and high mortality. miRNAs play a critical role in the tumorigenesis of HCC, but the underlying mechanism...

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Main Authors: Chunjing Wang (Author), Chengcheng Li (Author), Rui Hao (Author)
Format: Book
Published: Hindawi Limited, 2022-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Chunjing Wang  |e author 
700 1 0 |a Chengcheng Li  |e author 
700 1 0 |a Rui Hao  |e author 
245 0 0 |a miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3 
260 |b Hindawi Limited,   |c 2022-01-01T00:00:00Z. 
500 |a 1466-1861 
500 |a 10.1155/2022/3121492 
520 |a Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and has a high mortality rate. Although prevention and treatment of HCC has improved, it still faces poor prognosis and high mortality. miRNAs play a critical role in the tumorigenesis of HCC, but the underlying mechanism has not been well investigated. Here, the functions and interaction between miR-559 and PARD3 were investigated in HCC cells. Increased PARD3 and decreased miR-559 expression were observed in HCC cells compared with those in normal liver cells, especially in Huh-7 cells. Studies further demonstrated that PARD3 silencing or miR-559 overexpression impaired the proliferation, autophagy, and angiogenesis in Huh-7 cells. Mechanistically, PARD3 represents a target of miR-559. Furthermore, investigations revealed that miR-559 inhibition induced the expression of PARD3, thereby enhancing cell proliferation, autophagy, and angiogenesis in Huh-7 cells. These results reveal the interaction between miR-559 and PARD3 in HCC cells and provide new insights into their potential targets as therapeutic treatment against HCC. 
546 |a EN 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Mediators of Inflammation, Vol 2022 (2022) 
787 0 |n http://dx.doi.org/10.1155/2022/3121492 
787 0 |n https://doaj.org/toc/1466-1861 
856 4 1 |u https://doaj.org/article/f6238713024c46b5a5b4e5d00fb538b4  |z Connect to this object online.