Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat/rev Genes for an HIV-1 Gene Therapy Approach

• Main Authors: Francesca Spanevello (Author), Arianna Calistri (Author), Claudia Del Vecchio (Author), Barbara Mantelli (Author), Chiara Frasson (Author), Giuseppe Basso (Author), Giorgio Palù (Author), Marina Cavazzana (Author), Cristina Parolin (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy holds considerable promise for the functional cure of HIV-1 infection and, in this context, RNA interference (RNAi)-based approaches represent powerful strategies. Stable expression of small interfering RNAs (siRNAs) targeting HIV genes or cellular cofactors has the potential to render...