Impact of a Bundle of Interventions on Quality-of-Care Indicators for <i>Staphylococcus aureus</i> Bacteraemia: A Single-Centre, Quasi-Experimental, Before-After Study

• Main Authors: Giacomo Casalini (Author), Cristina Pagani (Author), Andrea Giacomelli (Author), Laura Galimberti (Author), Laura Milazzo (Author), Massimo Coen (Author), Serena Reato (Author), Beatrice Caloni (Author), Stefania Caronni (Author), Simone Pagano (Author), Samuel Lazzarin (Author), Anna Lisa Ridolfo (Author), Sara Giordana Rimoldi (Author), Andrea Gori (Author), Spinello Antinori (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Staphylococcus aureus</i> bacteraemia (SAB) is a life-threatening bloodstream infection. Improved adherence to quality-of-care indicators (QCIs) can significantly enhance patient outcomes. This quasi-experimental study evaluated the impact of a bundle of interventions on QCI adherence in adult patients with SAB. Additionally, a molecular rapid diagnostic test (mRDT) for <i>S. aureus</i> and methicillin resistance was introduced during weekdays. We compared pre-intervention (January-December 2022) and post-intervention (May 2023-April 2024) data on QCI adherence and time to appropriate treatment. A total of 56 and 40 SAB episodes were included in the pre- and post-intervention periods, respectively. Full QCI adherence significantly increased from 28.6% to 67.5% in the post-intervention period (<i>p</i> < 0.001). The mRDT diagnosed SAB in eight cases (26.6%), but the time to achieve appropriate target therapy did not improve in the post-intervention period (54 h (IQR 30-74) vs. 72 h (IQR 51-83), <i>p</i> = 0.131). The thirty-day mortality rate was comparable between the two periods (17.9% vs. 12.5%, <i>p</i> = 0.476). This study demonstrates that a bundle of interventions can substantially improve adherence to SAB management QCIs.

Item Description

10.3390/antibiotics13070646
2079-6382