Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

• Main Authors: Li-Xiang Ye (Author), Ying Xu (Author), Shui-Hua Zhang (Author), Da-Xuan Cao (Author), Ling-Fan Chen (Author), Yan-Ping Su (Author), Hui-Hui Huang (Author), Chang-Xi Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging leads to changes in nearly all pharmacokinetic phases. Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dose proportionality following oral administration in aged individuals remains unknown. Herein, we established a...