Miller Fisher syndrome with sinus arrest

Dysautonomia in Guillain-Barre syndrome (GBS) rarely causes serious cardiovascular complications, such as sinus arrest. Miller Fisher syndrome (MFS) is recognized as a variant of GBS. There have been few reports regarding the association between MFS and dysautonomia. We describe a case of a 68-year-...

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Main Authors: Nobuko Shiraiwa (Author), Mitsumasa Umesawa (Author), Sachiko Hoshino (Author), Tsuyoshi Enomoto (Author), Susumu Kusunoki (Author), Akira Tamaoka (Author), Norio Ohkoshi (Author)
Format: Book
Published: MDPI AG, 2017-08-01T00:00:00Z.
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Summary:Dysautonomia in Guillain-Barre syndrome (GBS) rarely causes serious cardiovascular complications, such as sinus arrest. Miller Fisher syndrome (MFS) is recognized as a variant of GBS. There have been few reports regarding the association between MFS and dysautonomia. We describe a case of a 68-year-old man with ophthalmoplegia, bulbar palsy, truncal ataxia, and areflexia. He was diagnosed with MFS because he exhibited the classical clinical triad and had elevated serum anti- GQ1b immunoglobulin G levels. A magnetic resonance imaging scan of his head was normal. His 24-hour Holter recording showed sinus arrest. He was treated with intravenous immunoglobulin, whereupon his symptoms gradually improved. This included the sinus arrest, which was considered a symptom of dysautonomia in MFS. Therefore, clinicians should be mindful of dysautonomia not only in GBS patients, but also in cases of MFS.
Item Description:2035-8385
2035-8377
10.4081/ni.2017.7312