Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma

• Main Authors: Yingqiang Liu (Author), Zhengsheng Zhan (Author), Zhuang Kang (Author), Mengyuan Li (Author), Yongcong Lv (Author), Shenglan Li (Author), Linjiang Tong (Author), Fang Feng (Author), Yan Li (Author), Mengge Zhang (Author), Yaping Xue (Author), Yi Chen (Author), Tao Zhang (Author), Peiran Song (Author), Yi Su (Author), Yanyan Shen (Author), Yiming Sun (Author), Xinying Yang (Author), Shanyan Yao (Author), Hanyu Yang (Author), Caixia Wang (Author), Meiyu Geng (Author), Wenbin Li (Author), Wenhu Duan (Author), Hua Xie (Author), Jian Ding (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults and is poorly controlled. Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression, and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for G...