Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies

Abstract Background Previous studies have reported that long-term use of valproic acid can cause changes in bone metabolism in children. We conducted this meta-analysis to determine the effects of valproic acid on bone metabolism and bone mineral density (BMD) in children with epilepsy. Methods Stud...

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Main Authors: Li Min (Author), Wang Chunyan (Author), Rong Biaoxue (Author)
Format: Book
Published: BMC, 2020-03-01T00:00:00Z.
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001 doaj_f69b2a6e23b14ea9a53cdbc57a52fd97
042 |a dc 
100 1 0 |a Li Min  |e author 
700 1 0 |a Wang Chunyan  |e author 
700 1 0 |a Rong Biaoxue  |e author 
245 0 0 |a Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies 
260 |b BMC,   |c 2020-03-01T00:00:00Z. 
500 |a 10.1186/s12887-020-1984-7 
500 |a 1471-2431 
520 |a Abstract Background Previous studies have reported that long-term use of valproic acid can cause changes in bone metabolism in children. We conducted this meta-analysis to determine the effects of valproic acid on bone metabolism and bone mineral density (BMD) in children with epilepsy. Methods Studies were searched from the databases of PubMed, Embase, Ovid, Cochrance Library, Springer Link and Web of Science. The effects of valproic acid on bone metabolism indicators and BMD were assessed through calculating the standardized mean difference (SMD) with 95% confidence interval (CI). Results Fourteen studies with 987 individuals were included in this analysis. The long-term use of valproic acid did not affect the levels of serum calcium (p = 0.99), phosphorus (p = 0.28), ALP (p = 0.76), PTH (p = 0.36) and osteocalcin (p = 0.72), but it led to a decrease in 25-OH-VitD (p = 0.01) and BMD (p = 0.002 for the vertebra; p = 0.004 for the femur) in treating children with epilepsy. Conclusion Long-term use of valproic acid in treating children with epilepsy can lead to a reduction in 25-OH-VitD and BMD. Measurements of 25-OH-VitD and BMD should be performed regularly in children taking the drug to detect early osteopenia caused by the drug. 
546 |a EN 
690 |a Valproic acid 
690 |a Epilepsy; children 
690 |a Bone metabolism 
690 |a Bone mineral density 
690 |a Meta-analysis 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n BMC Pediatrics, Vol 20, Iss 1, Pp 1-12 (2020) 
787 0 |n http://link.springer.com/article/10.1186/s12887-020-1984-7 
787 0 |n https://doaj.org/toc/1471-2431 
856 4 1 |u https://doaj.org/article/f69b2a6e23b14ea9a53cdbc57a52fd97  |z Connect to this object online.