Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy

• Main Authors: S. Rossi (Author), R. Maisto (Author), C. Gesualdo (Author), M. C. Trotta (Author), F. Ferraraccio (Author), M. K. Kaneva (Author), S. J. Getting (Author), E. Surace (Author), F. Testa (Author), F. Simonelli (Author), P. Grieco (Author), F. Merlino (Author), M. Perretti (Author), M. D'Amico (Author), C. Di Filippo (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice. At 12-16 weeks after diabetes induction, fluorescein angiography (FAG) revealed an approximate incidence of 80% microvascular chang...