Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): A single-center, single-blinded, randomized, controlled clinical trial

• Main Authors: Jianbin Guan (Author), Yuping Liao (Author), Yuexun Guo (Author), Shuang Yu (Author), Rongjuan Wei (Author), Mengwei Niu (Author), Jianwei Gan (Author), Lu Zhang (Author), Tong Li (Author), Jin Lv (Author), Maoyou Shichen (Author), Ping Chang (Author), Peng Chen (Author), Zhanguo Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: In preclinical experiments, we demonstrated that the 5-HT3 receptor antagonist granisetron results in reduced inflammation and improved survival in septic mice. This randomized controlled trial was designed to assess the efficacy and safety of granisetron in patients with sepsis.Methods:...