Escin's Action on Bradykinin Pathway: Advantageous Clinical Properties for an Unknown Mechanism?

Escin, extracted from horse chestnut (<i>Aesculus hippocastanum</i>) has anti-edema and anti-inflammatory effects. It is used to treat several clinical conditions, including venous insufficiency, pain, inflammation, and edema. Considering escin's pharmacodynamic, the inhibition of t...

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Main Authors: Gianmarco Marcianò (Author), Cristina Vocca (Author), Demirhan Dıraçoğlu (Author), Rotinda Özdaş Sevgin (Author), Luca Gallelli (Author)
Format: Book
Published: MDPI AG, 2024-09-01T00:00:00Z.
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001 doaj_f79809d42f3b4a7bac1d945341f62c8e
042 |a dc 
100 1 0 |a Gianmarco Marcianò  |e author 
700 1 0 |a Cristina Vocca  |e author 
700 1 0 |a Demirhan Dıraçoğlu  |e author 
700 1 0 |a Rotinda Özdaş Sevgin  |e author 
700 1 0 |a Luca Gallelli  |e author 
245 0 0 |a Escin's Action on Bradykinin Pathway: Advantageous Clinical Properties for an Unknown Mechanism? 
260 |b MDPI AG,   |c 2024-09-01T00:00:00Z. 
500 |a 10.3390/antiox13091130 
500 |a 2076-3921 
520 |a Escin, extracted from horse chestnut (<i>Aesculus hippocastanum</i>) has anti-edema and anti-inflammatory effects. It is used to treat several clinical conditions, including venous insufficiency, pain, inflammation, and edema. Considering escin's pharmacodynamic, the inhibition of the bradykinin pathway represents a particular effect, decreasing the local edema and conferring an advantage in comparison to other compounds. In this narrative review, we described the effects of escin considering its effects on bradykinin pathway. 
546 |a EN 
690 |a escin 
690 |a bradykinin 
690 |a hippocastanum 
690 |a inflammation 
690 |a edema 
690 |a venous insufficiency 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Antioxidants, Vol 13, Iss 9, p 1130 (2024) 
787 0 |n https://www.mdpi.com/2076-3921/13/9/1130 
787 0 |n https://doaj.org/toc/2076-3921 
856 4 1 |u https://doaj.org/article/f79809d42f3b4a7bac1d945341f62c8e  |z Connect to this object online.