Tofacitinib May Inhibit Myofibroblast Differentiation from Rheumatoid-Fibroblast-like Synoviocytes Induced by TGF-β and IL-6

• Main Authors: Piero Ruscitti (Author), Vasiliki Liakouli (Author), Noemi Panzera (Author), Adriano Angelucci (Author), Onorina Berardicurti (Author), Elena Di Nino (Author), Luca Navarini (Author), Marta Vomero (Author), Francesco Ursini (Author), Daniele Mauro (Author), Vincenza Dolo (Author), Francesco Ciccia (Author), Roberto Giacomelli (Author), Paola Cipriani (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During rheumatoid arthritis (RA), the pathogenic role of resident cells within the synovial membrane is suggested, especially for a population frequently referred to as fibroblast-like synoviocytes (FLSs). In this study, we assess the markers of myofibroblast differentiation of RA-FLSs by ex vivo ob...