Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial

• Main Authors: Sharon M. Rymut (Author), Siddharth Sukumaran (Author), Gizette Sperinde (Author), Meire Bremer (Author), Joshua Galanter (Author), Kenta Yoshida (Author), Jordan Smith (Author), Prajna Banerjee (Author), Viyia Sverkos (Author), Fang Cai (Author), Verena Steffen (Author), Lindsay M. Henderson (Author), Horace Rhee (Author), Paula N. Belloni (Author), Joseph H. Lin (Author), Tracy L. Staton (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tryptase is the most abundant secretory granule protein in human lung mast cells and plays an important role in asthma pathogenesis. MTPS9579A is a novel monoclonal antibody that selectively inhibits tryptase activity by dissociating active tetramers into inactive monomers. The safety, tole...