DISEASE RECURRENCE PREDICTORS FOR PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA

• Main Authors: Yuniardini S. Wimardhani (Author), D. M. Walker (Author), J. R. Gibbins (Author), M. J. Veness (Author), G. J. Morga (Author), I. I. Kalains (Author)
• Format: Book
• Published: Faculty of Dentistry, Universitas Indonesia, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1693-9697; 2355-4800; 10.14693/jdi.v13i3.348
• Keywords: Squamous cell carcinoma; head and neck; predictor; Dentistry; RK1-715
• Source: Journal of Dentistry Indonesia, Vol 13, Iss 3 (2015)

Information on reliable factors to predict patient outcome is important for deciding upon the best treatment to increase loco-regional control, overall survival and quality of life of patients with head and neck squamous cell carcinoma (HNSCC). The objective of this study was to investigate the role of clinico-pathological parameters as predictors of disease recurrence in patients with HSNCC. We studied fifty patients who were seeking treatment for primary HSNCC in Westmed Hospital between 2002 - 2004. Univariate analysis was used to identify any significant association between clinico-pathological parameters and disease recurrence. It was showed that age (p=0.008), cTNM stage (p=0.02), size of tumour (p=0.009) and positive tumour margin (p=0.002) predicted the risk of the development of disease recurrence. A longer follow-up study should be performed to assess the significance of these factors on overall survival as well as separate studies on prognostic indicators for patients with histologically negative lymph node.