Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer's disease models

• Main Authors: Xiu Yang (Author), Yuan-Hao Chen (Author), Le Liu (Author), Zheng Gu (Author), Yue You (Author), Jing-Ru Hao (Author), Nan Sun (Author), Can Gao (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a large-scale proteomic analysis. It's wel...