Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
ABSTRACTReceptor occupancy assays applied in clinical studies provide insights into pharmacokinetic-pharmacodynamic relationships for therapeutic antibodies. When measured by different assays, however, receptor occupancy results can be controversial, as was observed for nivolumab, a monoclonal antib...
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| Format: | Book |
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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