Determination of 20(S)-protopanaxadiol in human plasma by HPLC-MS/MS: application to a pharmacokinetic study

• Main Authors: Feifan Xie (Author), Sanwang Li (Author), Zeneng Cheng (Author), Xingling Liu (Author), Hong Zhang (Author), Peijiong Li (Author), Zhi Liu (Author), Xin Guo (Author), Peng Yu (Author)
• Format: Book
• Published: Elsevier, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid, specific and sensitive HPLC-MS/MS method was developed and validated for the determination of 20(S)-protopanaxadiol (PPD) in human plasma. PPD and the internal standard PD were extracted from plasma by liquid-liquid extraction with cyclohexane-methylene dichloride (2:1, v/v). The separation...