Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

• المؤلفون الرئيسيون: Yubo Wang (مؤلف), Jian Min (مؤلف), Xiangping Deng (مؤلف), Tian Feng (مؤلف), Hebing Hu (مؤلف), Xinyi Guo (مؤلف), Yan Cheng (مؤلف), Baohua Xie (مؤلف), Yu Yang (مؤلف), Chun-Chi Chen (مؤلف), Rey-Ting Guo (مؤلف), Chune Dong (مؤلف), Hai-Bing Zhou (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrine-resistance. Given...