Population pharmacokinetic modeling of paired plasma-breast milk lamivudine data for estimation of infant exposure in breastfeeding mother-infant pairs

• Main Authors: Francis Williams Ojara (Author), Aida N. Kawuma (Author), Shadia Nakalema (Author), Isabella Kyohairwe (Author), Ritah Nakijoba (Author), Mohammed Lamorde (Author), Henry Pertinez (Author), Saye Khoo (Author), Catriona Waitt (Author)
• Format: Bog
• Udgivet: Wiley, 2024-11-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Around 1.2 million women living with HIV give birth annually, majority of whom will breastfeed their infants while receiving antiretroviral therapy (ART). Lamivudine, a component of first‐line ART regimens crosses from maternal plasma to breast milk, with measurable concentrations in some b...