Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents

• मुख्य लेखकों: Vu Q. Nguyen (लेखक), Kristin Eden (लेखक), Holly A. Morrison (लेखक), Megan B. Sammons (लेखक), Kristin K. Knight (लेखक), Siena Sorrentino (लेखक), Rebecca M. Brock (लेखक), Douglas J. Grider (लेखक), Irving C. Allen (लेखक), Dario Sorrentino (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD). Unfortunately, a significant number of patients fail to respond or lose response over time to these agen...