Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

• Main Authors: Arnaud Billet (Author), Ahmad Elbahnsi (Author), Mathilde Jollivet-Souchet (Author), Brice Hoffmann (Author), Jean-Paul Mornon (Author), Isabelle Callebaut (Author), Frédéric Becq (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the functional consequence of rare cystic fibrosis (CF) mutations is mandatory for the adoption of precision therapeutic approaches for CF. Here we studied the effect of the very rare CF mutation, W361R, on CFTR processing and function. We applied western blot, patch clamp and pharmaco...