TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

• Auteurs principaux: Eric J. Bryan (Auteur), Hye Yeon Sagong (Auteur), Ajit K. Parhi (Auteur), Mark C. Grier (Auteur), Jacques Y. Roberge (Auteur), Edmond J. LaVoie (Auteur), Daniel S. Pilch (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongasome protein in most Gram-negative bacterial rods. H...