Effect of Antibodies Against Intercellular Adhesion Molecule-1, B7, and CD40 on Interleukin-18-Treated Human Mixed Lymphocyte Reaction

• Main Authors: Hideo Kohka Takahashi (Author), Hiromi Iwagaki (Author), Ryuji Tamura (Author), Takahito Yagi (Author), Tadashi Yoshino (Author), Shuji Mori (Author), Noriaki Tanaka (Author), Masahiro Nishibori (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection. Keywords:: interleukin-18, mixed lymphocyte reaction, adhesion molecule

Item Description

1347-8613
10.1254/jphs.sc0040167