System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides. The intracellular imbalance between oxidant and antioxidant due to the abnormal expression of multiple redox ac...
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Frontiers Media S.A.,
2022-08-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Feng-Jiao Li |e author |
| 700 | 1 | 0 | |a Feng-Jiao Li |e author |
| 700 | 1 | 0 | |a Hui-Zhi Long |e author |
| 700 | 1 | 0 | |a Hui-Zhi Long |e author |
| 700 | 1 | 0 | |a Zi-Wei Zhou |e author |
| 700 | 1 | 0 | |a Zi-Wei Zhou |e author |
| 700 | 1 | 0 | |a Hong-Yu Luo |e author |
| 700 | 1 | 0 | |a Hong-Yu Luo |e author |
| 700 | 1 | 0 | |a Shuo-Guo Xu |e author |
| 700 | 1 | 0 | |a Shuo-Guo Xu |e author |
| 700 | 1 | 0 | |a Li-Chen Gao |e author |
| 700 | 1 | 0 | |a Li-Chen Gao |e author |
| 245 | 0 | 0 | |a System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy |
| 260 | |b Frontiers Media S.A., |c 2022-08-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.910292 | ||
| 520 | |a The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides. The intracellular imbalance between oxidant and antioxidant due to the abnormal expression of multiple redox active enzymes will promote the produce of reactive oxygen species (ROS). So far, a few pathways and regulators have been discovered to regulate ferroptosis. In particular, the cystine/glutamate antiporter (System Xc−), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System Xc−/GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System Xc−/GSH/GPX4 axis. This review aims to present the current understanding of the mechanism of ferroptosis based on the System Xc−/GSH/GPX4 axis in the treatment of drug-resistant solid tumors. | ||
| 546 | |a EN | ||
| 690 | |a system Xc -/GSH/GPX4 axis | ||
| 690 | |a ferroptosis | ||
| 690 | |a drug resistance | ||
| 690 | |a solid tumor | ||
| 690 | |a therapy | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.910292/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f8d6ed1fba1a4a5ca5b0d3345a21dd21 |z Connect to this object online. |