Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish

• Main Authors: Ana M. Vacaru (Author), Antonio Fabio Di Narzo (Author), Deanna L. Howarth (Author), Orkhontuya Tsedensodnom (Author), Dru Imrie (Author), Ayca Cinaroglu (Author), Salma Amin (Author), Ke Hao (Author), Kirsten C. Sadler (Author)
• Format: Book
• Published: The Company of Biologists, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of hundreds of targets. UPR activation can resul...