Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells

• Main Authors: Masayuki Fujiwara (Author), Hikaru Yamamoto (Author), Tatsuhiro Miyagi (Author), Takahiro Seki (Author), Shigeru Tanaka (Author), Izumi Hide (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The serotonin transporter (SERT) is involved in various psychiatric disorders, including depression and autism. Recently, chemical chaperones have been focused as potential therapeutic drugs that can improve endoplasmic reticulum (ER) stress-related pathology. In this study, we used SERT-transfected...