A High Throughput Cell-Based Screen Assay for LINE-1 ORF1p Expression Inhibitors Using the In-Cell Western Technique

• Main Authors: Yanni Kou (Author), Shujie Wang (Author), Yanjie Ma (Author), Ning Zhang (Author), Zixiong Zhang (Author), Qian Liu (Author), Yang Mao (Author), Rui Zhou (Author), Dongrong Yi (Author), Ling Ma (Author), Yongxin Zhang (Author), Quanjie Li (Author), Jing Wang (Author), Jinhui Wang (Author), Xile Zhou (Author), Chunnian He (Author), Jiwei Ding (Author), Shan Cen (Author), Xiaoyu Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long interspersed nuclear element 1 (LINE-1) is a dominant autonomous retrotransposon in human genomes which plays a role in affecting the structure and function of somatic genomes, resulting in human disorders including genetic disease and cancer. LINE-1 encoded ORF1p protein which possesses RNA-bi...