Clinical analyses of 30 cases of progressive macular hypomelanosis
Objective: To explore the clinical characteristics of progressive macular hypomelanosis and its treatment. Methods: Retrospective analyses of the clinical manifestations and treatment efficacy were made in 30 patients with progressive macular hypomelanosis from October 2013 to October 2018. Results:...
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| Main Authors: | , , , |
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| Format: | Book |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology,
2019-10-01T00:00:00Z.
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| Summary: | Objective: To explore the clinical characteristics of progressive macular hypomelanosis and its treatment. Methods: Retrospective analyses of the clinical manifestations and treatment efficacy were made in 30 patients with progressive macular hypomelanosis from October 2013 to October 2018. Results: The main clinical manifestations of progressive macular hypomelanosis were unclear rounded and scaleless hypopigmented macules, with some merge at the center, on the trunks. Microscopic examination for fungi was negative.Spotted red fluorescence on the hypopigmented lesion was visible under the wood lamp. Under confocal scanning microscope, normal pigment rings in all cases and reduced pigment particles in 25 cases were observed.Following 10-week treatments with isotretinoin-erythromycin gel combined with NB-UVB(narrow-band ultraviolet B) radiation twice a week, total effective rate was 80.00%, including 10 cured, 7 almost cured, 7 markedly improved, 3 improved and 3 unimproved. Conclusions: Because progressive macular hypomelanosis is asymptomatic, with minimal clinical manifestations and without specific laboratory examination, it can be easily neglected or misdiagnosed.Topical isotretinoin-erythromycin gel combined with narrow-band ultraviolet B radiation is safe and effective, which is worthy of clinical popularization. |
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| Item Description: | 1674-8468 10.3969/j.issn.1674-8468.2019.05.005 |