Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery
BackgroundMultisystem inflammatory syndrome (MIS) in children is considered to be a post-infectious complication of COVID-19. T-cell responses in children with this condition have not been well-studied.MethodsWe aimed to study the immune responses in children with MIS in comparison to children with...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2023-12-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_f9c05af30afc49859a2a4ea2a4792a1f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Nathella Pavan Kumar |e author |
| 700 | 1 | 0 | |a Kadar M. Abbas |e author |
| 700 | 1 | 0 | |a Rachel M. Renji |e author |
| 700 | 1 | 0 | |a Aishwarya Venkataraman |e author |
| 700 | 1 | 0 | |a Arul Nancy |e author |
| 700 | 1 | 0 | |a Poovazhagi Varadarjan |e author |
| 700 | 1 | 0 | |a Elilarasi Selladurai |e author |
| 700 | 1 | 0 | |a Thankgavelu Sangaralingam |e author |
| 700 | 1 | 0 | |a Ramya Selvam |e author |
| 700 | 1 | 0 | |a Akshith Thimmaiah |e author |
| 700 | 1 | 0 | |a Suresh Natarajan |e author |
| 700 | 1 | 0 | |a Ganesh Ramasamy |e author |
| 700 | 1 | 0 | |a Syed Hissar |e author |
| 700 | 1 | 0 | |a Uma Devi Ranganathan |e author |
| 700 | 1 | 0 | |a Thomas B. Nutman |e author |
| 700 | 1 | 0 | |a Subash Babu |e author |
| 700 | 1 | 0 | |a Subash Babu |e author |
| 245 | 0 | 0 | |a Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery |
| 260 | |b Frontiers Media S.A., |c 2023-12-01T00:00:00Z. | ||
| 500 | |a 2296-2360 | ||
| 500 | |a 10.3389/fped.2023.1235342 | ||
| 520 | |a BackgroundMultisystem inflammatory syndrome (MIS) in children is considered to be a post-infectious complication of COVID-19. T-cell responses in children with this condition have not been well-studied.MethodsWe aimed to study the immune responses in children with MIS in comparison to children with acute COVID-19 and children with other infections. Whole blood was stimulated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antigens and flow cytometry was performed to examine CD4+ and CD8+ T-cell responses.ResultsChildren with MIS had higher frequencies of CD4+ and CD8+ T cells expressing cytokines at baseline and upon SARS-CoV-2 antigen-specific stimulation in comparison to children with COVID-19 and/or other infections. Children with COVID-19 also exhibited higher frequencies of CD4+ and CD8+ T cells expressing cytokines at baseline and upon SARS-CoV-2 antigen-specific stimulation in comparison to children with other infections. At 6-9 months following treatment and recovery, this enhanced response against SARS-CoV-2 antigens was down modulated in children with MIS.ConclusionOur study, therefore, provides evidence of enhanced activation of CD4+ and CD8+ T-cell responses in children with MIS and reversal following recovery. | ||
| 546 | |a EN | ||
| 690 | |a MIS-C | ||
| 690 | |a SARS-CoV-2 | ||
| 690 | |a COVID-19 | ||
| 690 | |a CD4+ T cells | ||
| 690 | |a CD8+ T cells | ||
| 690 | |a cellular immune responses | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pediatrics, Vol 11 (2023) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fped.2023.1235342/full | |
| 787 | 0 | |n https://doaj.org/toc/2296-2360 | |
| 856 | 4 | 1 | |u https://doaj.org/article/f9c05af30afc49859a2a4ea2a4792a1f |z Connect to this object online. |